Anti-inflammatory drugs analysis in a wastewater sewage treatment plant and surface water in semiarid climate
DOI:
https://doi.org/10.5327/Z2176-94781629Keywords:
domestic effluents; drugs; effluent treatment; water quality; urban rivers; emerging contaminantsAbstract
This work aimed to analyze the presence of four common molecules (diclofenac, dipyrone, ibuprofen, and paracetamol) in the Ipojuca River, in the stretch of Caruaru municipality (Brazil), and in a wastewater treatment plant that discharges treated water to the river. Collections were conducted for three months at each point during April, May, and June. The samples were collected in three repetitions (sample, replica, and triplicate). Through Pearson’s correlation, the correlation between ibuprofen and diclofenac concentration and rainfall in the region was also verified. These drugs were detected in 100% of the samples, with concentrations between 7.4–548.2 and 81.8–231.8 μg.L-1, respectively. Paracetamol and dipyrone were not detected. The observed high concentrations are due to the high consumption of drugs and the low rate of sewage collection in the municipality. Both analyzed drugs — ibuprofen and diclofenac — had insignificant correlation results with rainfall (-0.022 and -0.071, respectively). Regarding the drugs in the WWTP, the treatment consisting of anaerobic followed by aerated lagoons showed efficiency ranging from 35.9 to 93.6% in the removal of diclofenac. The removal of ibuprofen was higher in April (86.6%), but in the other two months, it did not prove to be efficient, evidencing the need to implement more adapted technologies in the removal of drugs combined with the network expansion for sewage collection in the region. A study with longer time monitoring is needed to understand the rainfall effect on drug concentration in the river.
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Américo, J.H.P.; Isique, W.D.; Minillo, A.; Carvalho, S.L.; Torres, N.H., 2012. Drugs in a sewage treatment plant in the Midwest region of Brazil and the risks to water resources. Revista Brasileira de Recursos Hídricos, v. 17, (3), 61-67. https://doi.org/10.21168/rbrh.v17n3.p61-67
Américo-Pinheiro, J.H.P.; Isique, W.D.; Torres, N.H.; Machado, A.A.; Carvalho, S.L.; Valério Filho, W.V.; Ferreira, L.F.R., 2017. Ocorrência de diclofenaco e naproxeno em água superficial no município de Três Lagoas (MS) e a influência da temperatura da água na detecção desses anti-inflamatórios. Engenharia Sanitária e Ambiental, v. 22, (3), 429-435. https://doi.org/10.1590/s1413-41522017128719
Agência Nacional de Águas (ANA), 2017. Elaboração de proposta de plano de ação para instituir política de reúso de efluentes sanitários tratados no Brasil (Accessed November 21, 2020) at:. https://antigo.mdr.gov.br/images/stories/ArquivosSNSA/interaguas/reuso/produto2_experiencias_de_reuso.pdf.
Agência Nacional de Vigilância Sanitária (ANVISA), 2018. Anuário Estatístico do Mercado Farmacêutico (Accessed January 19, 2021) at:. http://portal.anvisa.gov.br/medicamentos/publicacoes?tagsName=cmed.
Agência Pernambucana de Águas e Climas (APAC), 2020 (Accessed August 15, 2020) at:. http://www.apac.pe.gov.br/.
Ashfaq, M.; Khan, K.N.; Rehman, M.S.U.; Mustafa, G.; Nazar M.F.; Sun, Q.; Iqbal, J.; Mulla, S.I.; Yu, C.P., 2017. Ecological assessment risk of pharmaceuticals in the receiving environment of pharmaceutical wastewater in Pakistan. Ecotoxicology and Environmental Safety, v. 136, 31-39. https://doi.org/10.1016/j.ecoenv.2016.10.029
Batt, A.L.; Furlong, E.T.; Mash, H.E.; Glassmeyer, S.T.; Kolpin, D.W., 2017. The importance of quality control in validating concentrations of contaminants of emerging concern in source and treated drinking water samples. Science of the Total Environment, v. 579, 1618-1628. https://doi.org/10.1016/j.scitotenv.2016.02.127
Brasil. Conselho Nacional do Meio Ambiente (CONAMA), 2005. Resolução CONAMA n. 357, de 17 de março de 2005. Diário Oficial da União, Brasília.
Bueno, M.J.M.; Gomez, M.J.; Herrera, S.; Hernando, M.D.; Agüera, A.; Fernández-Alba, A.R., 2012. Occurrence and persistence of emerging organic contaminants and priority pollutants in five sewage treatment plants of Spain: two years pilot survey monitoring. Environmental Pollution, v. 164, 267-273. https://doi.org/10.1016/j.envpol.2012.01.038
Carvalho Filho, J.A.A.; Cruz, H.M.; Fernandes, B.S.; Motteran, F.; Paiva, A.L.R.; Cabral, J.J.S.P., 2022. Efficiency of the bank filtration technique for diclofenac removal: a review. Environmental Pollution, v. 300, 118916. http://doi.org/10.1016/j.envpol.2022.118916
Companhia Pernambucana de Saneamento (COMPESA), 2016. Plano de comunicação do programa de saneamento ambiental da bacia do rio Ipojuca (Accessed August 7, 2020) at:. https://servicos.compesa.com.br/wp-content/uploads/2016/02/MI-Plano-Comunica%C3%A7%C3%A3o-ajustada.pdf
Companhia Pernambucana de Saneamento (COMPESA), 2019. Nota Técnica - Panorama de reuso na COMPESA (Accessed June 15, 2021) at:. https://servicos.compesa.com.br/wp-content/uploads/2020/12/3-ANEXO-III-004.2020-Nota-Tecnica-Panorama-do-reuso-na-COMPESA-v....pdf
Agência Estadual de Planejamento e Pesquisas de Pernambuco (CONDEPE-FIDEM), 2005. Bacia Hidrográfica do Rio Ipojuca: Série Bacias Hidrográficas de Pernambuco (Accessed December 10, 2020) at:. http://www.condepefidem.pe.gov.br/c/document_library/get_file?p_l_id=78673&folderId=141869&name=DLFE-12005.pdf
El-Kalliny, A.S.; Abdel-Wahed, M.S.; El-Zahhar, A.A.; Hamza, I.A.; Gad-Allah, T.A., 2023. Nanomaterials: a review of emerging contaminants with potential health or environmental impact. Discover Nano, v. 18, 1-21. http://doi.org/10.1186/s11671-023-03787-8
Floripes, T.C.; Aquino, S.F.; Quaresma, A.V.; Afonso, R.J.C.F.; Chernicharo, C.A.L.; Souza, C.L., 2018. Occurrence of drugs and endocrine disruptors in raw and treated sewage in the city of Belo Horizonte (MG). Sanitary and Environmental Engineering, v. 23, (6), 1199-1211. https://doi.org/10.1590/S1413-41522018177703
Gómez, M.J.; Bueno, M.J.M.; Lacorte, S.; Fernandez-Alba, A.R.; Agüera, A., 2007. Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere, v. 66, (6), 993-1002. https://doi.org/10.1016/j.chemosphere.2006.07.051
Gómez-Canela, C.; Pueyo, V.; Barata, C.; Lacorte, S.; Marcé, R.M., 2019. Development of predicted environmental concentrations to prioritize the occurrence of pharmaceuticals in rivers from Catalonia. Science of the Total Environment, v. 666, 57-67. https://doi.org/10.1016/j.scitotenv.2019.02.078
Hanif, H.; Waseem, A.; Kali, S.; Qureshi, N.A.; Majid, M.; Iqbal, M.; Ur-Rehman, T.; Tahir, M.; Yousaf, S.; Iqbal, M.M.; Khan, A.I.; Zafar, M.I., 2020. Environmental risk assessment of diclofenac residues in surface waters and wastewater: a hidden global threat to aquatic ecosystem. Environmental Monitoring and Assessment, v. 192, 1-12. https://doi.org/10.1007/s10661-020-8151-3
Hawash, H.B.; Moneer, A.A.; Galhoum, A.A.; Elgarahy, A.M.; Mohamed, W.A. A; Samy, M.; El-Seedi, H.R.; Gaballah, M.S.; Mubarak, M.F.; Attia, N.F., 2023. Occurrence and spatial distribution of pharmaceuticals and personal care products (PPCPs) in the aquatic environment, their characteristics, and adopted legislations. Journal Of Water Process Engineering, v. 52, 103490. https://doi.org/10.1016/j.jwpe.2023.103490
Henschel, K.P.; Wenzel, A.; Diedrich, M.; Fliedner, A., 1997. Environmental hazard assessment of pharmaceuticals. Regulatory Toxicology and Pharmacology, v. 25, 220-225. https://doi.org/10.1006/rtph.1997.1102
Kasprzyk-Hordern, B.; Dinsdale, R.M.; Guwy, A.J., 2009. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Research, v. 43, 363-380. https://doi.org/10.1016/ j.watres.2008.10.047
Kermia, A.E.B.; Fouial-Djebbar, D.; Trari, M., 2016. Occurrence, fate and removal efficiencies of pharmaceuticals in wastewater treatment plants (WWTPs) discharging in the coastal environment of Algiers. Comptes Rendus Chimie, v. 19, 963-970. https://doi.org/10.1016/j.crci.2016.05.005
Kosma, C.I.; Lambropoulou, D.A.; Albanis, T.A., 2010. Occurrence and removal of PPCPs in municipal and hospital wastewaters in Greece. Journal of Hazardous Materials, v. 179, p. 804-817. https://doi.org/10.1016/j.jhazmat.2010.03.075
Koumaki, E.; Mamais, D.; Noutsopoulos, C., 2017. Environmental fate of nonsteroidal anti-inflammatory drugs in river water/sediment systems. Journal of Hazardous Materials, v. 323, 233-241. https://doi.org/10.1016/j.jhazmat.2016.03.026
Kramer, R.D.; Mizukawa, A.; Ide, A.H.; Marcante, L.O.; Santos, M.D.; Azevedo, J.D., 2015. Determination of anti-inflammatories in water and sediment and their relationship with water quality in the Alto Iguaçu basin, Curitiba-PR. Brazilian Journal of Water Resources, v. 20, (3), 657-667. https://doi.org/10.21168/rbrh.v20n3.p657-667
Kumar, M.; Sridharan, S.; Sawarkar, A.D.; Shakeel, A.; Anerao, P.; Mannina, G.; Sharma, P.; Pandey, A., 2023. Current research trends on emerging pharmaceutical contaminants and personal care products (PPCPs): a comprehensive review. Science of the Total Environment, v. 859, 160031. https://doi.org/10.1016/j.scitotenv.2022.160031
Lee, S.H.; Kim, K.H.; Lee, M.; Lee, B.D., 2019. Detection status and removal characteristics of pharmaceuticals in wastewater treatment effluent. Journal of Water Process Engineering, v. 31, 100828. https://doi.org/10.1016/j.jwpe.2019.100828
Lopes, V.S.A.; Riente, R.R.; Silva, A.A.; Torquilho, D.F.; Silva Carreira, R.; Costa Marques, M.R., 2016. Development of a solid-phase extraction system modified for preconcentration of emerging contaminants in large sample volumes from rivers of the lagoon system in the city of Rio de Janeiro, Brazil. Marine Pollution Bulletin, v. 110, (1), 572-577. https://doi.org/10.1016/j.marpolbul.2016.05.059
Mandaric, L.; Mor, J.R.; Sabater, S.; Petrovic, M., 2018. Impact of urban chemical pollution on water quality in small, rural and effluent-dominated Mediterranean streams and rivers. Science of the Total Environment, v. 613, 763-772. https://doi.org/10.1016/j.scitotenv.2017.09.128
Medeiros, R.M., 2020. Climatic analysis of the Ipojuca River Basin-PE. Brazilian Journal Of Agroecology And Sustainability, v. 2, (1), 1-17. https://doi.org/10.52719/bjas.v2i1.3087
Migowska, N.; Caban, M.; Stepnowski, P.; Kumirska, J., 2012. Simultaneous analysis of non-steroidal anti-inflammatory drugs and estrogenic hormones in water and wastewater samples using gas chromatography–mass spectrometry and gas chromatography with electron capture detection. Science of the Total Environment, v. 441, 77-88. https://doi.org/10.1016/j.scitotenv.2012.09.043
Mlunguza, N.Y.; Ncube, S.; Mahlambi, P.N.; Chimuka, L.; Madikizela, L.M., 2019. Adsorbents and removal strategies of non-steroidal anti-inflammatory drugs from contaminated water bodies. Journal of Environmental Chemical Engineering, v. 7, 103142. https://doi.org/10.1016/j.jece.2019.103142
Moldovan, Z., 2006. Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania. Chemosphere, v. 64, 1808-1817. https://doi.org/10.1016/j.chemosphere.2006.02.003
Montagner, C.C.; Jardim, W.F., 2011. Spatial and seasonal variations of pharmaceuticals and endocrine disruptors in the Atibaia River, São Paulo State (Brazil). Journal of the Brazilian Chemical Society, v. 22, 1452-1462. https://doi.org/10.1590/S0103-50532011000800008
Montagner, C.C.; Vidal, C.C.; Acayaba, R.D., 2017. Emerging contaminants in aquatic matrices in Brazil: current scenario and analytical, ecotoxicological and regulatory aspects. New Chemistry, v. 40, 1094-1110. https://doi.org/10.21577/0100-4042.20170091
Monteiro, R.T.; Santana, R.M.R.; Silva, A.M.R.B.; Lucena, A.L.A.; Zaidan, L.E.M.C.; Silva, V.L.; Napoleão, D.C., 2018. Degradation of the pharmaceuticals nimesulide and ibuprofen using photo-Fenton process: toxicity studies, kinetic modeling and use of artificial neural networks. REGET, 22, e3. https://doi.org/10.5902/2236117031563
Nagarajan, A.M.; Subramanian, A.; Gobinathan, K.P.; Mohanakrishna, G.; Sivagami, K., 2023. Electrochemical-based approaches for the treatment of pharmaceuticals and personal care products in wastewater. Journal Of Environmental Management, v. 344. https://doi.org/10.1016/j.jenvman.2023.118385
Napoleão, D.C.; Zaidan, LE.M.C.; Diaz, J.M.R.; Santana, R.M.R.; Montenegro, M.C.B.; Araujo, A.N.; Benachour, M.; Silva, V.L., 2018. Use of the photo-Fenton process to discover the degradation of drugs present in water from the Wastewater Treatment Plants of the pharmaceutical industry. Affinity, v. 75, 23-31.
Oliveira, R.; Almeida, M.F.; Santos, L.; Madeira, L.M., 2006. Experimental design of 2,4-dichlorophenol oxidation by fenton's reaction. Industrial & Engineering Chemistry Research, v. 45, 1266-1276. https://doi.org/10.1021/ie0509544
Osorio, V.; Marcé, R.; Pérez, S.; Ginebreda, A.; Cortina, J.L.; Barceló, D., 2012. Occurrence and modeling of pharmaceuticals on a sewage-impacted Mediterranean river and their dynamics under different hydrological conditions. Science of the Total Environment, v. 440, 3-13. https://doi.org/10.1016/j.scitotenv.2012.08.040
Palli, L.; Spina, F.; Varese, G.C.; Vincenzi, M.; Aragno, M.; Arcangeli, G.; Gori, R., 2019. Occurrence of selected pharmaceuticals in wastewater treatment plants of Tuscany: An effect-based approach to evaluate the potential environmental impact. International Journal of Hygiene and Environmental Health, v. 222, 717-725. https://doi.org/10.1016/j.ijheh.2019.05.006
Paranhos, R.; Figueiredo Filho, D.B.; Rocha, E.C.; Silva Júnior, J.A.; Paranhos, R.; Neves, J.A.B.; Silva, M.B., 2014. Desvendando os mistérios do coeficiente de correlação de Pearson: o retorno. Leviathan (São Paulo), (8), 66-95. https://doi.org/10.11606/issn.2237-4485.lev.2014.132346
Patrolecco, L.; Capri, S.; Ademollo, N., 2015. Occurrence of selected pharmaceuticals in the main sewage treatment plants in Rome (Italy) and in the receiving surface waters. Environmental Science and Pollution Research, v. 22, 5864-5876. https://doi.org/10.1007/s11356-014-3765-z
Pereira, A.M.P.T.; Silva, L.J.G.; Meisel, L.M.; Lino, C.M.; Pena, A., 2015. Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment. Environmental Research, v. 136, 108-119. https://doi.org/10.1016/j.envres.2014.09.041
Pereira, C.D.S.; Maranho, L.A.; Cortez, F.S.; Pusceddu, F.H.; Santos, A.R.; Ribeiro, D.A.; Guimaraes, L.L., 2016. Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone. Science of the Total Environment, v. 548, 148-154. https://doi.org/10.1016/j.scitotenv.2016.01.051
Pinto, G.M.F.; Silva, K.R.D.; Pereira, R.D.F.A.B.; Sampaio, S., 2014. Study of residential disposal of expired drugs in the region of Paulínia (SP), Brazil. Sanitary and Environmental Engineering, v. 19, 219-224. https://doi.org/10.1590/S1413-41522014019000000472
Praveena, S.M.; Shaifuddin, S.N.M.; Sukiman, S.; Nasir, F.A.M.; Hanafi, Z.; Kamarudin, N.; Aris, A.Z., 2018. Pharmaceuticals residues in selected tropical surface water bodies from Selangor (Malaysia): occurrence and potential risk assessments. Science of the Total Environment, v. 642, 230-240. https://doi.org/10.1016/j.scitotenv.2018.06.058
Radović, T.; Grujić, S.; Petković, A.; Dimkić, M.; Laušević, M., 2015. Determination of pharmaceuticals and pesticides in river sediments and corresponding surface and groundwater in the Danube River and tributaries in Serbia. Environmental Monitoring and Assessment, v. 187, (1), 1-17. https://doi.org/10.1007/s10661-014-4092-z
Rastogi, A.; Tiwari, M.K.; Ghangrekar, M.M., 2021. A review on environmental occurrence, toxicity and microbial degradation of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Journal Of Environmental Management, v. 300, 113694. https://doi.org/10.1016/j.jenvman.2021.113694
Richardson, S.D.; Kimura, S.Y., 2017. Emerging environmental contaminants: challenges facing our next generation and potential engineering solutions. Environmental Technology & Innovation, v. 8, 40-56. https://doi.org/10.1016/j.eti.2017.04.002
Rivera-Jaimes, J.A.; Postigo, C.; Melgoza-Alemán, R.M.; Aceña, J.; Barceló, D.; Alda, M.L., 2018. Study of pharmaceuticals in surface and wastewater from Cuernavaca, Morelos, Mexico: Occurrence and environmental risk assessment. Science of the Total Environment, v. 613, 1263-1274. https://doi.org/10.1016/j.scitotenv.2017.09.134
Rosal, R.; Rodríguez, A.; Perdigón-Melón, J.A.; Petre, A.; García-Calvo, E.; Gómez, M.J.; Fernández-Alba, A.R., 2010. Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation. Water Research, v. 44, (2), 578-588. https://doi.org/10.1016/j.watres.2009.07.004
Sari, S.; Ozdemir, G.; Yangin-Gomec, C.; Zengin, G.E.; Topuz, E.; Aydin, E.; Tas, D.O., 2014. Seasonal variation of diclofenac concentration and its relation with wastewater characteristics at two municipal wastewater treatment plants in Turkey. Journal of Hazardous Materials, v. 272, 155-164. https://doi.org/10.1016/j.jhazmat.2014.03.015
Schmidt, S.; Hoffmann, H.; Garbe, L.; Schneider, R.J., 2018. Liquid chromatography–tandem mass spectrometry detection of diclofenac and related compounds in water samples. Journal of Chromatography A, v. 1538, 112-116. https://doi.org/10.1016/j.chroma.2018.01.037
Shanmuganathan, R.; Kadri, M.S.; Mathimani, T.; Le, Q.H.; Pugazhendhi, A. 2023. Recent innovations and challenges in the eradication of emerging contaminants from aquatic systems. Chemosphere, v. 332. https://doi.org/10.1016/j.chemosphere.2023.138812
Sibeko, P.A.; Naicker, D.; Mdluli, P.S.; Madikizela, L.M., 2019. Naproxen, ibuprofen, and diclofenac residues in river water, sediments and Eichhornia crassipes of Mbokodweni river in South Africa: an initial screening. Environmental Forensics, v. 20, (2), 129-138. https://doi.org/10.1080/15275922.2019.1597780
Silva, E.R.A.C.I.; Galvíncio, J.D., 2011. The MWSP Global Scope Methodology Applied at the Local Level for the Analysis of Hydrological Stress in the Middle Section of the Ipojuca Basin- PE: a Contribution to the Thematic of Transposition of the São Francisco River. Brazilian Journal of Physical Geography, v. 4, (3), 602-628. https://doi.org/10.26848/rbgf.v4i3.232738
Sistema de Informação de Recursos Hídricos (SNIRH), 2019. Atlas Esgotos: Base de Dados de Estações de Tratamento de Esgotos no Brasil (Accessed September 14, 2020) at:. http://www.snirh.gov.br/portal/snirh/snirh-1/atlas-esgotos.
Sistema Nacional de Informações sobre Saneamento (SNIS), 2021. Diagnóstico Temático Serviços de Água e Esgoto (Accessed December 21, 2021) at:. https://www.gov.br/mdr/pt-br/assuntos/saneamento/snis/produtos-do-snis/diagnosticos/DIAGNOSTICO_TEMATICO_VISAO_GERAL_AE_SNIS_2021.pdf
Souza, L.C.O.; Bezerra, S.T.M.; Amorim, J.M.B.S.; Alves, I.M.; Duarte, A.D., 2020. Avaliação de alternativas direcionadas à redução do consumo de água potável em residências: estudo de caso em Caruaru, PE, Brasil. Ambiente Construído, v. 20, (4), 465-487. https://doi.org/10.1590/s1678-86212020000400483
Secretaria de Recursos Hídricos e Energéticos (SRHE), 2010. Plano Hidroambiental da Bacia do Rio Ipojuca (PHA - Ipojuca) (Accessed September 20, 2020) at:. https://www.apac.pe.gov.br/images/media/1569523666_PHA_Ipojuca_TOMO_I_VOL_1_Diagnostico_10.09.11.pdf
Szabó, Z.; Szoboszlai, N.; Jambor, E.; Gulyás, G.; Lóránd, T.; Ohmacht, R.; Zaray, G.; Mihucz, V.G., 2013. Determination of four dipyrone metabolites in Hungarian municipal wastewater by liquid chromatography mass spectrometry. Microchemical Journal, v. 107, 152-157. https://doi.org/10.1016/j.microc.2012.08.006
Veras, T.B.; Paiva, A.L.R.; Duarte, M.M.M.B.; Napoleão, D.C.; Cabral, J.J.S.P., 2019. Analysis of the presence of anti-inflammatory drugs in surface water: A case study in Beberibe river-PE, Brazil. Chemosphere, v. 222, 961-969. https://doi.org/10.1016/j.chemosphere.2019.01.167
Vieno, N.; Sillanpää, M., 2014. Fate of diclofenac in municipal wastewater treatment plant — A review. Environment International, v. 69, 28-39. http://doi.org/10.1016/j.envint.2014.03.021
Wang, J.; He, B.; Yan, D.; Hu, X., 2017. Implementing ecopharmacovigilance (EPV) from a pharmacy perspective: A focus on non-steroidal anti-inflammatory drugs. Science of the Total Environment, v. 603, 772-784. https://doi.org/10.1016/j.scitotenv.2017.02.209
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